TUHH> ITB

Institute of Technical Biocatalysis

Reaction Sequences


Biocatalytic cascades and one-pot multi-step enzymatic reactions have attracted growing interest owing to several important advantages:

(i) Minimized isolation and purification steps required for obtaining complex molecules.

(ii) Higher product yields and productivities achieved by such designs.

(iii) Chemo-, regio-, and stereoselectivity of various biocatalysts.

 

Nowadays, redox enzymes that usually require expensive cofactors for the electron transfer between molecules are mostly coupled in a cascade fashion. This allows simultaneous cofactor regeneration enabling more efficient and economical oxidation as well as reduction.

 

Group Leader: Dr. Selin Kara


Research Fields

• Alternative cofactor regeneration systems for redox enzymes e.g., ‘smart cosubstrates’ and biocatalytic cascades.

• Multi-enzymatic and chemo-enzymatic cascades for chemical transformations.

• Process optimisation using Design of Experiments (DoEs).

• Stabilisation of enzymes by means of immobilisation and additives.


 

 


Reaction Sequences

News

New PhD position at ITB. Topic: Experimental and theoretical processing of biocatalytic cascade reactions.

New PhD position at ITB.

Topic: Experimental and theoretical processing of biocatalytic cascade reactions.

Complete offer information available here.

Edgar Gamero joins the ITB for his Master Thesis. Welcome!

Edgar Gamero joins the ITB for his Master Thesis. Welcome!

Edgar will work in the topic "Etablierung einer Hochzelldichtefermentation und eines Aktivitätstest zur Oxidation von Alkanen".

Good luck and welcome!

Dr. Martina Schedler has succesfully completed her PhD!

Martina Schedler has succesfully completed her PhD "Microbial degradation of crude oil at high pressure".

Congratulations!!

Aparna Nair joins the ITB for her Master's Project Work. Welcome!
Aparna Nair joins the ITB for her Master's Project Work. Welcome!

Aparna will work in the topic "Optimization of crude oil fractionation procedures for biodegradation analysis at high pressure conditions".

Good luck and welcome!